Interleukin-23 receptor

Interleukin 23 receptor

Identifiers

External IDs

OMIM: 607562 MGI: 2181693 HomoloGene: 16930 GeneCards: IL23R Gene

Gene Ontology
Molecular function	• receptor activity • interleukin-12 receptor binding • interleukin-23 binding • interleukin-23 receptor activity
Cellular component	• plasma membrane • integral to membrane • interleukin-23 receptor complex
Biological process	• positive regulation of T cell mediated cytotoxicity • positive regulation of defense response to virus by host • positive regulation of defense response to virus by host • positive regulation of T-helper 1 type immune response • positive regulation of T-helper 1 type immune response • inflammatory response • positive regulation of activation of JAK2 kinase activity • response to lipopolysaccharide • negative regulation of interleukin-10 production • positive regulation of granulocyte macrophage colony-stimulating factor production • positive regulation of interferon-gamma production • positive regulation of interferon-gamma production • positive regulation of interferon-gamma production • positive regulation of interleukin-12 production • positive regulation of interleukin-17 production • positive regulation of natural killer cell proliferation • response to interferon-gamma • positive regulation of T cell proliferation • positive regulation of activated T cell proliferation • regulation of tyrosine phosphorylation of Stat1 protein • positive regulation of tyrosine phosphorylation of Stat3 protein • positive regulation of tyrosine phosphorylation of Stat4 protein • positive regulation of tyrosine phosphorylation of Stat5 protein • positive regulation of memory T cell differentiation • positive regulation of osteoclast differentiation • defense response to Gram-negative bacterium • positive regulation of NK T cell activation • positive regulation of T-helper 17 type immune response • positive regulation of T-helper 17 cell lineage commitment
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
67.63 – 67.73 Mb

Chr 6:
67.37 – 67.44 Mb

PubMed search

[1]

[2]

Interleukin 23 receptor is a type I cytokine receptor. IL23R is its human gene.^[1]

The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.^[1]

References

^ ^a ^b "Entrez Gene: IL23R interleukin 23 receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=149233.

Parham C, Chirica M, Timans J, et al. (2002). "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.". J. Immunol. 168 (11): 5699–708. PMID 12023369.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Zhang XY, Zhang HJ, Zhang Y, et al. (2006). "Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells.". Immunogenetics 57 (12): 934–43. doi:10.1007/s00251-005-0067-0. PMID 16372191.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Duerr RH, Taylor KD, Brant SR, et al. (2006). "A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.". Science 314 (5804): 1461–3. doi:10.1126/science.1135245. PMID 17068223.
Cargill M, Schrodi SJ, Chang M, et al. (2007). "A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.". Am. J. Hum. Genet. 80 (2): 273–90. doi:10.1086/511051. PMC 1785338. PMID 17236132. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1785338.
Dubinsky MC, Wang D, Picornell Y, et al. (2007). "IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease.". Inflamm. Bowel Dis. 13 (5): 511–5. doi:10.1002/ibd.20126. PMC 2169293. PMID 17309073. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2169293.
Tremelling M, Cummings F, Fisher SA, et al. (2007). "IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease.". Gastroenterology 132 (5): 1657–64. doi:10.1053/j.gastro.2007.02.051. PMC 2696256. PMID 17484863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2696256.
Cummings JR, Ahmad T, Geremia A, et al. (2007). "Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype.". Inflamm. Bowel Dis. 13 (9): 1063–8. doi:10.1002/ibd.20180. PMID 17508420.
Yamazaki K, Onouchi Y, Takazoe M, et al. (2007). "Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients.". J. Hum. Genet. 52 (7): 575–83. doi:10.1007/s10038-007-0156-z. PMID 17534574.
Baldassano RN, Bradfield JP, Monos DS, et al. (2007). "Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease.". Clin. Gastroenterol. Hepatol. 5 (8): 972–6. doi:10.1016/j.cgh.2007.04.024. PMID 17618837.
Sánchez E, Rueda B, Callejas JL, et al. (2007). "Analysis of interleukin-23 receptor (IL23R) gene polymorphisms in systemic lupus erythematosus.". Tissue Antigens 70 (3): 233–7. doi:10.1111/j.1399-0039.2007.00881.x. PMID 17661912.
Orozco G, Rueda B, Robledo G, et al. (2007). "Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort.". Hum. Immunol. 68 (8): 681–4. doi:10.1016/j.humimm.2007.05.008. PMID 17678723.
Oliver J, Rueda B, López-Nevot MA, et al. (2007). "Replication of an association between IL23R gene polymorphism with inflammatory bowel disease.". Clin. Gastroenterol. Hepatol. 5 (8): 977–81, 981.e1–2. doi:10.1016/j.cgh.2007.05.002. PMID 17678845.
Raelson JV, Little RD, Ruether A, et al. (2007). "Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.". Proc. Natl. Acad. Sci. U.S.A. 104 (37): 14747–52. doi:10.1073/pnas.0706645104. PMC 1965486. PMID 17804789. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1965486.
Borgiani P, Perricone C, Ciccacci C, et al. (2007). "Interleukin-23R Arg381Gln is associated with susceptibility to Crohn's disease but not with phenotype in an Italian population.". Gastroenterology 133 (3): 1049–51; author reply 1051–2. doi:10.1053/j.gastro.2007.07.013. PMID 17854611.

Cytokine receptors

Chemokine receptor
(GPCRs)

CC	CCR1/CCRL1 · CCR2 · CCRL2 · CCR3 · CCR4 · CCR5 · CCR6 · CCR7 · CCR8 · CCR9 · CCR10

CXC	IL-8 (CXCR1, CXCR2) · CXCR3 · CXCR4 · CXCR5 · CXCR6 · CXCR7

Other	CX3C (CX3CR1) · XC (XCR1) · CCBP2 · CMKLR1

TNF receptor

1-10	TNFRSF1 (CD120) · TNFRSF1A (CD120a) · TNFRSF1B (CD120b) · TNFRSF3 (Lymphotoxin beta receptor) · TNFRSF4 (CD134) · TNFRSF5 (CD40) · TNFRSF6 (FAS) · TNFRSF6B · TNFRSF7 (CD27) · TNFRSF8 (CD30) · TNFRSF9 (CD137)

11-20	TNFRSF10A (CD261) · TNFRSF10B (CD262) · TNFRSF10C (CD263) · TNFRSF10D (CD264) · TNFRSF11A (CD265/RANK) · TNFRSF11B (Osteoprotegerin) · TNFRSF12A (CD266) · TNFRSF13B (CD267) · TNFRSF13C · TNFRSF14 (CD268) · TNFRSF16 (Nerve growth factor receptor) · TNFRSF17 (CD269) · TNFRSF18 · TNFRSF19

21-25	TNFRSF21 · TNFRSF25 · TNFRSF27

JAK-STAT

Type I

γ-chain	Interleukin receptors (IL2R/IL2RA/IL2RB/IL15R, IL4R/IL13R/IL13RA1/IL13RA2, IL7R/IL7RA, IL9R, IL21R)

β-chain	Interleukin receptors (IL3R/IL3RA, IL5R/IL5RA) · GM-CSF

gp130	Interleukin receptors (IL6RA, 11/IL11RA, 27/IL27RA) · OSMR · LIFR · CNTFR

IL12RB1	Interleukin receptors (IL12R/IL12RB1/IL12RB2, IL23R23)

Other	other CSF receptors (EPO, G-CSF, Thrombopoietin) hormone receptor: GH · prolactin

Type II

Interleukin receptors (IL10R/IL10RA/IL10RB/IL22R/IL22RA2, IL20R/IL20RA/IL20RB, IL28R) · Interferon receptors (-α/β/IFNAR1/IFNAR2, -γ/IFNGR1/IFNGR2)

Ig superfamily

CSF1 · KIT · IL1 (IL1R1, IL1R2) · IL18R/IL18R1

IL-17 family

IL-17 (IL17RA, IL17RB, IL17RC, IL17RD, IL17RE)

S/T

TGF-beta (TGFBR1, TGFBR2)

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

Interleukin-23 receptor

References

Further reading